Abstract
A series of 2-phenylspiroindenes was prepared. The most active analogue (2) was found to be comparable in potency to raloxifene (1) as an estrogen receptor ligand.
MeSH terms
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Alkylation
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Animals
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Borohydrides
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Crystallography, X-Ray
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Humans
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In Vitro Techniques
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Indenes / chemical synthesis*
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Indenes / pharmacology*
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Indicators and Reagents
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Raloxifene Hydrochloride / pharmacology
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Rats
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Receptors, Estrogen / drug effects
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Selective Estrogen Receptor Modulators / chemical synthesis*
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Selective Estrogen Receptor Modulators / pharmacology*
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / pharmacology*
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Structure-Activity Relationship
Substances
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2-Phenylspiroindene
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Borohydrides
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Indenes
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Indicators and Reagents
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Receptors, Estrogen
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Selective Estrogen Receptor Modulators
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Spiro Compounds
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Raloxifene Hydrochloride
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sodium borohydride